Best Supplements for Mounjaro and Zepbound Users

Tirzepatide slows gastric emptying and reduces hunger signals more aggressively than semaglutide for many users. That often means even smaller portions, more constipation, and a higher risk of dehydration if you do not actively manage fluids and electrolytes.

It also produces some of the highest average weight loss numbers of any approved medication — up to 20–22% of body weight in clinical trials. That amount of weight loss without a serious protein plan is a recipe for lean mass loss.

Constipation is the #1 complaint on tirzepatide. It responds well to a three-part approach: 5–10 g of soluble fiber per day (psyllium or acacia), 300–400 mg of magnesium glycinate or citrate at night, and 80+ oz of water with a daily electrolyte serving.

If you have not moved your bowels in 3+ days despite all of the above, a short course of an osmotic laxative like MiraLAX is safe for most adults — clear it with your prescriber first.

Tirzepatide titrates monthly: 2.5 → 5 → 7.5 → 10 → 12.5 → 15 mg. Not everyone needs to reach 15 mg — many settle at 7.5 or 10 mg. Each increase brings a fresh wave of appetite suppression and potential nausea or fatigue for 3–7 days.

During those windows, prioritize hydration, magnesium, and liquid protein over solid food. Once you settle at a maintenance dose, your supplement routine becomes daily and predictable.