The Best Supplements to Take While on GLP-1 Medications
A ranked list of the best supplements to take on Ozempic, Wegovy, Mounjaro, and Zepbound — based on the side effects they prevent.
There are dozens of supplements marketed to GLP-1 users. The honest answer is that five or six of them do most of the work. The rest are nice-to-have.
Here is the ranked, no-fluff list of supplements that earn their place on a GLP-1 — based on the side effects they prevent and the nutrition gaps they actually fill.
The ranked list
- 1. Protein — the single most impactful supplement on a GLP-1
- 2. Electrolytes — prevent cramps, fatigue, and dehydration
- 3. Magnesium glycinate — sleep, regularity, muscle recovery
- 4. Daily multivitamin — backstop for missed vitamins and minerals
- 5. Probiotic + fiber — constipation, bloating, gut comfort
- 6. Vitamin D3 + K2 — mood, immunity, bone health
- 7. Omega-3 fish oil — inflammation, heart, brain
What you do not need
Skip the expensive 'metabolism boosters', 'GLP-1 boosters', and any supplement that claims to enhance the effect of your medication. There is no evidence they work and some can interact with your prescription.
Frequently asked questions
What is the single best supplement on a GLP-1?
Protein. Without adequate protein, every other supplement has to fight a losing battle against muscle loss. Start there.
How many supplements is too many?
If you are not taking what you have consistently, you have too many. Five or six is plenty for most users — and only if you take them every day.
Premium supplements formulated for GLP-1 wellness.